Cancer, COMT, TP53 & BRCA

Written by Joe Cohen, BS | Last updated:
hCG and cancer

This week we were all witness to Chadwick Boseman’s (AKA The Black Panther) death.

Colon cancer is the second-leading cause of cancer deaths in the U.S.

Anybody can get it. Nobody is immune. If you have a colon, you’re at risk.

9 out of 10 people who get colon cancer and catch it early will live longer. The problem is that people wait too long. They think, ‘Well I feel good. I don’t have any symptoms.’ Then the tumor spreads beyond the colon where it goes into other tissues, the bone, the brain etc… and now you have an increased risk of death.

Prevention and early detection is key.

That’s when knowing your genetic risks can be the difference between life or death.

The unfortunate truth is that the majority of the world has been affected by cancer in one way or another.

Once someone already has cancer, it’s not easy to get rid of. There are “alternative cancer cures”, but I don’t think that most of these proposed solutions actually work, and they certainly aren’t properly tested.

Your genes give you the power to be proactive, instead of reactive, and implement a preventative lifestyle that will help you decrease your risk of developing deadly health issues like cancer, before it’s too late.

Some of the most studied genes in genomics have been found to have strong correlations to cancer development, specifically BRCA1, BRCA2, TP53, and COMT.

So, we’ve created reports for all of these genes that allow you to learn your genetic risks for cancer and discover personalized recommendations so that you can start lowering your risks now.


1 in 8 women will develop invasive breast cancer over the course of her lifetime. That’s already a high statistic, but for women carrying a BRCA1 mutation, it’s even worse. Their risk for developing breast cancer increases to 51% at 50, and 84% after 70.

BRCA1 and BRCA2 are two of the best-known “tumor suppressor” genes. These genes prevent the development of cancer through several different mechanisms, including repairing DNA damage, controlling the “cell cycle,” and regulating the expression of various other genes throughout the body.

But the gene mutations decrease their function, which increases your susceptibility to cancer.

The BRCA DNA Report analyzes your BRCA genes, shows you what genetic variant you carry, and provides you with personalized recommendations that you can implement to increase BRCA gene expression and decrease your risk of cancer.

TP53 and the P53 Protein

The TP53 gene is so important in cancer prevention that more than 50% of cancer patients were found to have the negative TP53 gene variants.

TP53 codes for the protein p53, which plays a key role in preventing cancer by activating hundreds of genes with cancer-fighting functions.

The negative variant decreases the production of p53, so other genes responsible for cancer prevention functions like cell damage repair stay dormant, leaving you more vulnerable to develop cancer.

You need to get the TP53 DNA Report to understand your variant and implement your prioritized suggestions to increase p53 levels.

COMT and Estrogen

Estrogen breakdown results in byproducts that can cause oxidative stress and DNA damage, which in turn may turn cells cancerous.

Your COMT gene breaks down these byproducts and produces very important anti-cancer compounds. Therefore, low COMT activity levels can potentially lead to increased risk of cancer.

Our NEW COMT DNA Report is the only report on the market that can accurately measure your COMT activity in the brain so that you can implement lifestyle changes that will help break down these by-products and optimize your health for any future risk.

Using All 3 DNA Reports

The combination of all 3 reports will help you build a lifestyle that can dramatically decrease your risk of developing cancer, and also optimize your overall health.

Being proactive and taking preventative measures is the best approach you can take to avoid developing any health issue.

When you sign up for SelfDecode today, you’ll get access to ALL THREE of these reports (BRCA Report, TP53 Report, COMT Report), and two additional reports (or any 5 reports of your choice) to help you completely optimize your health.

Like always, with a SelfDecode membership, you’ll get access to all these amazing other features as well:

  • Access to ALL of your personalized results on the SelfDecode blog to check your genetic scorecards and see what you need to change to combat bad genes.
  • Ability to track and analyze your lab test results to get diet, lifestyle and supplement recommendations that will help you get your levels in the optimal range.
  • Unlimited AD-FREE access to SelfHacked.com, the world-renowned health information website.

Order a SelfDecode DNA kit with your subscription to get your genes analyzed or upload your DNA file from another company to get your results right away. We accept files from 23andMe, Ancestry, whole genome files and many more!

About the Author

Joe Cohen, BS

Joe Cohen, BS

As a kid, Joe suffered from inflammation, brain fog, fatigue, digestive problems, mood and other issues that were poorly understood in both conventional and alternative medicine.Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers.Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer.His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.

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