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Chronic Fatigue Syndrome Imbalances & Treatment Protocol

Written by Joe Cohen, BS | Last updated:

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People with chronic fatigue syndrome have high inflammation, unbalanced immunity, and low antioxidant status. Learn what to look for here.

Any kind of chronic inflammation will make you fatigued all of the time, so it may be hard to differentiate.

However, the first thing I look for is Th2 dominance, which is the immune profile in CFS.

What Causes CFS?

Chronic fatigue syndrome

It seems like CFS is a result of a viral infection and the body’s inability to control it. The result is oxidative stress.

This isn’t a post on how to combat CFS, but the general idea is to rebalance your immune system by increasing Th1, decreasing oxidative stress and reducing some kinds of inflammation.

This means that the mechanisms to control viruses are low and other kinds of inflammation might be high.

Your Doc Won’t Order These Tests

The problem is no doctor or will order these tests. As I understand it, doctors are under pressure from insurance companies and insurance companies are out for profit.

They don’t want to shell out thousands of dollars on tests if they don’t see a clear way to benefit from these tests.

People with CFS show elevated:

One must keep in mind that one test will not tell you if you have CFS. You need to take many of these tests to put a picture together.

People with CFS show decreased:

  • EPA [3]
  • Zinc [3, 16]
  • DHEAS [17] – contradictory [18]
  • Glutathione/GSH (cortical) [11]
  • Natural Killer Cell Activity/Cytotoxic activity of NK and CD8+T cells [5]
  • LPS-stimulated TGF-b [7]
  • HDL [2]
  • CD56bright NK cells [5] – CD56 Bright NK Cells are also lower in Coronary Heart Disease, Asthma, Rhinitis [19]
  • Granzyme A and granzyme K [5]
  • CD11b [8]
  • CD69 activation marker on T cells (CD3+, CD3+CD4+, and CD3+CD8+) and on NK cells (CD45+CD56+) – Since induction of CD69 surface expression is dependent on the activation of the protein kinase C (PKC) activation pathway, it is suggested that in CFS there is a disorder in the early activation of the immune system involving PKC [20].
  • DPPIV/C26 expressed on T cells and NK cells [21]
  • Neutrophil respiratory burst [22]
  • White matter in the midbrain [23]
  • PM Cortisol and 24hr urine free cortisol [24]
  • Folinic acid/Folate/Methylation [25, 26]
  • Bilateral white matter volumes [27]


Gut Dysfunction – altered intestinal microbiota, mucosal barrier dysfunction [28].

Lesions in frontal white matter [29].

Corticotropin-releasing hormone (CRH) and neurotensin (NT), secreted under stress, activate mast cells (MC) necessary for allergic reactions to release inflammatory mediators that could contribute to CFS symptoms [30].

No difference in GPx [31].

“Almost every adolescent with CFS had orthostatic tachycardia (Stewart et al.,1999), but this was not the case with adults (Natelson et al., 2007) where rates appear to be lower ranging from 10% (Naschitz et al., 2006) to 27% (Hoad et al., 2008) with the higher rate found in UK patients who reported having the diagnosis of CFS rather than being directly diagnosed. In our own study of adult patients (Natelson et al., 2007), orthostatic tachycardia was not common, occurring in only 11% of patients, not significantly different from rates in healthy controls” [29].

“Finding subgroups of CFS suggests different underlying pathophysiological processes responsible for the symptoms seen” [29].

About the Author

Joe Cohen, BS

Joe Cohen, BS

As a kid, Joe suffered from inflammation, brain fog, fatigue, digestive problems, mood and other issues that were poorly understood in both conventional and alternative medicine. Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers. Joe is a thriving entrepreneur, author and speaker. He is the CEO and founder of SelfDecode. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.


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