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NOS3, PON1 & CNR1 Genes: Personalized Genetics Blog Roundup! Get In Your Partner’s Genes

Written by Joe Cohen, BS | Last updated:

Since they’re saying that sex is no longer safe due to coronavirus, you might be looking for other things to occupy your time.

I’ve been keeping busy with studying my NOS3, PON1 and CNR1 genes, and using the Personalized Genetics Blog to look at all the different areas of my health that these genes can affect.

We’ve had a ton of new articles going up recently and one thing that has become even more apparent to me is how having certain variants for a gene can affect different areas of your health in different ways. Depending on the topic, my scorecard for a gene can be completely opposite.

It’s actually fun comparing your scorecards with your partner. Here’s some of my favorite articles from the SelfDecode Personalized Genetics Blog that you should check out:

NOS3 Genes

Can This Gene Benefit Your Athletic Performance?

When you have the genetic variants for NOS3 that I do, it means that your athletic performance can suffer due to the gene’s effect on heart rate and energy balance. However, if improving your athletic performance is important to you, there are some specific supplements you can take to get the most out of your workout.

Can This Gene Protect You from Lung Failure?

Unfortunately, my NOS3 genetic variants are associated with a reduced production of nitric oxide and increased risk of ARDS. This means that my risk of severe complications from COVID-19 is higher. Therefore, I’ve added two specific supplements to my regimen as recommended in this blog article!

CNR1

How to Tell if You’re Lectin Sensitive Using Your Genetic Data?

This scorecard isn’t a surprise to me, because I’ve known for years that I’m sensitive to lectins and have to follow a strict lectin-free diet. However, this post reminded me of a lifestyle habit that I need to incorporate to help optimize my CNR1 gene and help reduce my lectin sensitivity.

Beat “Brain Fog” With The Cannabinoid System

Brain fog is one of my favorite topics because when I learned how to fix my brain fog issues, my life completely changed. I went from a broke college drop out to a successful owner of 4 companies. One of the suggestions from this article to improve my CNR1 gene has actually been one of the key factors in helping me completely get rid of brain fog.

The Link Between Cannabinoid System & Weight Gain

Even though my CNR1 genetic variants are not good when it comes to brain fog or lectin sensitivity, they are great for keeping my weight under control! This gene plays a crucial role in the cannabinoid system and since my cannabinoid system is underactive, this actually helps to decrease appetite and slow my metabolism. Check your CNR1 and learn how to control your weight!

PON1

Can This Gene Help You Live Longer?

Researchers have found that people who live over 100 have something in common: they tend to have a specific variant of the PON1 gene. Unfortunately, my PON1 gene doesn’t set me up for a long life, but this article told me about some specific fruits I can eat to increase PON1 expression and expand my lifespan.

The Gene That Protects Your Heart

Heart disease is one of the leading causes of death in the world. Fortunately, PON1 protects your heart by clearing away fats in your blood. Unfortunately, genetic variants like mine can impact how well PON1 works. I plan to live a long life and that’s why I’ve incorporated all of the foods suggested in this article to help protect my heart and significantly boost my PON1 activity.

Is This Detox Gene Protecting You From Pesticides?

This article is interesting to me because even though I knew pesticides are bad, I didn’t realize that they are specifically worse for ME because of my genes! Check your PON1 gene to find out if pesticides are more dangerous for you than the average person.


No matter how long I study my own genes, it’s always entertaining to compare them with someone in my life. It’s interesting to see how the same gene can affect you and your partner so differently! Date night went from dinner and a movie to dinner and comparing genetic risk.

If you can’t explore your partner physically, now is a good time to explore what makes them who they are – and what better way to do that than exploring their DNA.

It’s always easier to make a change alongside someone else, so share these articles and get motivated to be your best self together!

About the Author

Joe Cohen, BS

Joe Cohen, BS

As a kid, Joe suffered from inflammation, brain fog, fatigue, digestive problems, mood and other issues that were poorly understood in both conventional and alternative medicine.Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers.Joe is a thriving entrepreneur, author and speaker. He is the CEO of SelfHacked, SelfDecode and LabTestAnalyzer.His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.

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