5 Gut Killers + 1 Silent Killer You Might Not Know About

Written by Joe Cohen, BS | Last updated:

Today, we’re talking about gut killers.

We already know that these 5 things can absolutely wreck your gut if you aren’t careful.

1. Alcohol

2. Stress

3. Sugar

4. Antibiotics

5. Processed food

But, what about when you’ve got all these under control and your gut is still out of whack? You could be suffering from silent gut killers, which are different for each person.

Everyone has their own “personalized” silent gut killers that are determined by your own genes.

That’s right, certain genetic variants can create some of the same situations within your body as the 5 gut killers above.

That was my problem. I’d already cut out everything I was supposed to and was still experiencing all sorts of gut-related issues like, inflammation, upset stomach, brain fog, mood issues…you name it, I had it.

When I realized that my genes were to blame, it was a game changer. Using my genes, I was able to implement personalized lifestyle changes to solve my unique gut killers.

If you’ve got gut issues, then you absolutely have to check your genes. You can start with some of the ones listed below because they all play key roles in your gut health.

In particular, the Th1/Th2/Th17 immune system plays a critical role in gut health. Th1 and Th17 dominance can wreck your gut if they get too high.

Here are 3 important genes that you need to know about (and check for yourself) that can tell you if your Th1/Th17 immune system is contributing to your gut problems. In addition, you should follow the recommendations if you see red faces on the posts.

Plus, keep reading to the end to find out how you can check all of your gut health genes at once!

IL-10 and Th1/Th17 Balance

IL-10 is one of the most important anti-inflammatory cytokines, as it helps control the immune system in the gut by suppressing the activity of Th1 cells.

The negative variant of the IL-10 gene reduces your IL-10 levels, which makes you more prone to gut inflammation and to your immune system attacking the beneficial bacteria that live in your gut.

However, if you carry the negative variant, there’s one supplement that is extremely effective in keeping your IL-10 levels high so that you keep a healthy balance of beneficial gut bacteria.

IRF5 and Inflammatory Cytokines

The IRF5 gene promotes Th1 and Th17 inflammatory cytokines in response to invading pathogens. When regulated, this effectively protects your gut against threats.

Unfortunately, one variant of the IRF5 gene has a lot of negative effects. It can stimulate too many inflammatory cytokines which causes gut inflammation and damage, and it suppresses IL-10, allowing inflammation to run even more rampant.

Based on your genetic variant, there’s one fruit that you can implement into your diet that contains the only natural substance found to directly reduce IRF5.

SH2B3 and Gluten

The SH2B3 gene helps balance the immune response by regulating Th1 cells and pro-inflammatory cytokines.

If you carry the negative variant, your SH2B3 gene will not properly regulate your immune system, and Th1 dominance may occur.

With Th1 dominance, your body will start attacking your gut for consuming foods that contain glutens or lectins, which can lead to major food sensitivity issues.

If you carry the negative variant, there’s one specific elimination diet that you need to implement to keep your gut healthy!

How To Check All of Your Gut Health Genes

To solve and improve your gut health, you have to have a balanced gut, and the best way you can do that is by using your genes to implement changes in your regimen that are based on your unique DNA.

Remember, your gut is responsible for so many different body functions, so when you’re healing and optimizing your gut health, you’re actually doing so much more for your body.

It’ll feel like a domino effect, as an improved gut will result in improvements to your mood, cognitive function, and so much more.

Fortunately, there’s a very easy way to check ALL the genes related to gut health and find out what the most important changes are for your body. With the SelfDecode Gut Inflammation DNA report, we’ll look at the 3 genes listed above, along with 42,930 other genetic variants related to gut health. This is the FULLEST picture of your health that science can currently to offer.

Plus, it’s so easy to start seeing results right away. We give you a prioritized list of personalized diet, lifestyle, and supplement recommendations that will work better than anything else you’ve tried because they’re based on your body.

These aren’t generic recommendations, they are specific to your genes. Believe me when I say that you won’t find a report like this anywhere else.

When you sign up for SelfDecode, you’ll receive your personalized Gut Inflammation DNA Report, plus:

  • Unlimited Personalized DNA Wellness Reports – more in-depth genetic reports on topics like gut health, mood, and sleep that provide you with recommendations specific for your body, so that you can solve any health problem you’re experiencing.
  • Lab Test Analyzer tool – Upload your lab results, look at markers related to gut, and discover how you can get your levels to the optimal range. We analyze over 1000 markers and will add any that we don’t have!
  • ALL SelfHacked articles (ad-free!) – Read from over 1500 science-based health articles that go in-depth on the benefits of natural supplement and lifestyle health changes, so you can understand exactly what you’re taking to optimize your gut.
  • and so much more!

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


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