Cholesterol, Berberine, & The LDLR Gene

Written by Joe Cohen, BS | Last updated:

This was NOT how I wanted my day to go.

It started off simple… with a call from my mother. She casually mentioned that she just started taking Lipitor, one of the most common drugs prescribed to people who have high cholesterol.

I was gutted to hear that she didn’t tell me she had high cholesterol in the first place. And there are SO many ways to improve your cholesterol levels naturally – why are prescription drugs the first and only place most people start?

Not to mention the fact that her son owns a personalized health company… I want to give people the option to make better health decisions – and that includes my mother.

So, I asked what else she’s doing to lower her cholesterol, besides this new drug. I heard a long silence before hearing that she was eating less red meat. Another long silence.

“That’s it?” I mentioned. Then I thought about it. This is probably what most people will think of when it comes to lowering their cholesterol levels. But it’s not enough.

Your Cholesterol Report, made just for you.

We’re challenging the way we see healthcare by giving you control of your own health plan. Every plan should be individualized, not just based on one or two symptoms.

Why? Because your body deserves better than generic. It needs a unique plan to get healthy, and stay healthy.

I went through my mom’s cholesterol report with her to help find new additions to her health plan that were completely tailored to her.

One of her top health recommendations was Berberine, a compound found in several different plants that have a long history of use in traditional Chinese and Indian medicine. But this recommendation didn’t come out of nowhere.

Supplementing with Berberine may reduce cholesterol more in people with her LDLR gene variant. The LDLR gene plays a huge role in regulating cholesterol levels in the blood, and some gene variants can cause high cholesterol.

Every health recommendation on her cholesterol report was made based on her unique gene variants and is backed by science, the latest research, and technology that virtually no one else is using in this space.

Now, I didn’t tell my mom to just stop her prescription medicine. But, I did tell her that she should take this report back to her doctor to discuss.

We’re not your average DNA company.

Most companies that claim to do what we do are only giving you a fraction of the information you really need. They analyze less data, use outdated methods, and offer generic health “insights” that are similar to what you might find with just one Google search.

We’re using the latest AI technology in genomics and machine learning to analyze millions of genetic variants in order to provide the actionable, personalized health recommendations you need to get your health back on track.

Here’s the thing: I want to live longer. I want my family to live longer. I want you to live longer. I started SelfDecode to help make that a reality, and my team of like-minded individuals is making that happen, one wellness report at a time.

The cholesterol report alone analyzes 1,171,067 genetic variants in order to provide more accurate and personalized diet, lifestyle, and supplement recommendations so you can make better health decisions, based on your DNA.

How many genetic variants are the other guys analyzing? A lot of them only test for the most common variants associated with any certain health condition, and many test less than a million in total. That means they’re missing a lot of the story when it comes to what makes you, you. SelfDecode analyzes up to 35 MILLION variants in total across all our reports, so you get the fullest picture of your health possible.

Everyone needs a unique plan when it comes to personalized health – and SelfDecode is as personalized as it gets.

Get access to your own personalized recommendations and help lower your cholesterol by checking your genes, and build a personalized health plan made just for you with SelfDecode.

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


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