Low Carb, Blood Sugar, and Melatonin

Written by Joe Cohen, BS | Last updated:

A lot of attendees have written to us that they find our webinars to be really helpful, so I wanted to share a question that I thought was interesting.

Question: I recently started using a continuous glucose monitor to track my levels throughout the day. I’ve been doing Keto for the last three years. What I’ve noticed is my glucose seems to rise while I’m sleeping. Can you explain why this happens?

Well, first of all what tends to happen with someone on a Ketogenic diet is that the increased consumption of fats tends to raise your fasting glucose levels.

Lots of people who do Keto might develop a slight glucose intolerance which is a reason that when doing a high fat or keto diet you really want to pay attention to your lab results.

It’s important to check and upload fasting glucose levels in SelfDecode’s Lab Analyzer.

A keto diet is great for a lot of things but there are some negatives to every diet. These increased fasting glucose levels are one of the potential negatives.

Why Can Keto Cause Higher Fasting Glucose?

First, some people get more insulin resistance with a higher fat diet, and this is highly dependent on genetics. People can have genetic variants that are more susceptible to high fat diets.

But I want to dive into one specific factor.

Lower carb diets may cause some insulin resistance as a result of lower melatonin.

Carbs are important for increasing serotonin, and serotonin is what the body uses to create melatonin.

Melatonin is useful for blood glucose balance and insulin sensitivity [1].

If you have a certain genetic variant in the melatonin gene (MTR1NB), you can be even more affected.

Check out your own results for this SNP variation here if you have uploaded your DNA file to a SelfDecode account. I have one of the negative genetic variants, which interferes with melatonin binding to its receptor and results in higher fasting glucose and risk of diabetes [1].

If you’re doing a low carb diet or having blood sugar regulation issues, you should check out this gene.

You should also take a look at your CLOCK gene which has established relationships with both your Circadian Rhythm Cycle and your Insulin levels. You can read about the CLOCK gene and ways to improve both your sleep and blood sugar levels in this SelfDecode Blog Post.



P.S. For information about Sleep and Blood Sugar in general, be sure to check out our comprehensive DNA Wellness Reports on both topics, and discover how to optimize your rest and your glucose levels.

About the Author

Joe Cohen, BS

Joe Cohen, BS

As a kid, Joe suffered from inflammation, brain fog, fatigue, digestive problems, mood and other issues that were poorly understood in both conventional and alternative medicine. Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers. Joe is a thriving entrepreneur, author and speaker. He is the CEO and founder of SelfDecode. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.


1 Star2 Stars3 Stars4 Stars5 Stars
(No Ratings Yet)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.