Evidence Based This post has 23 references
4 /5

PPAR Delta: Burn Fat & Become an Endurance Athlete

Written by Joe Cohen, BS | Last updated:

PPAR delta is important for heart function, energy production, endurance capacity, reducing inflammation and reducing obesity.

PPAR Delta Simple

PPARδ is a nuclear hormone receptor that governs a variety of biological processes and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer.

PPARδ may function as an integrator of sorts.

PPARδ helps prevent heart disease [1].

PPARδ is important for hair growth [2].

At higher levels, PPAR-δ increases fat burning in muscle and fat cells and increases energy expenditure. At lower levels, it helps create fat cells [3, 4].

PPARδ is found to be elevated in colorectal cancer cells.

Studies into the role of PPAR-δ in cancer have produced contradictory results and there is no scientific consensus on whether it promotes or prevents cancer formation [5].

PPARδ is involved with the absorption of fat and cholesterol (lipid uptake, such as fatty acid binding protein and fatty acid translocase). Also, it helps the growth of intestinal mucosa in response to fat [3].

PPARδ decreases inflammatory responses of macrophages and is linked to a significant rise in HDL cholesterol. PPAR activation in the liver decreases liver glucose output, thereby contributing to improved glucose tolerance and insulin sensitivity [6].

In a meta-analysis, PPAR delta was associated with height [7].

PPAR Delta Advanced

PPAR delta decreases Cannabinoid receptor expression [8].

PPAR delta decreases inflammatory cytokines such as TNF and macrophage-related inflammation (R). PPARδ helps prevent TNFα-induced apoptosis in skin cells [3].

PPAR delta is a potent inhibitor of activation of PPAR alpha and PPAR gamma [9].

PPAR delta inhibits the Th1 and Th17 immune systems [10] and combats autoimmunity [11], and causes weight loss.

Treatment of obese animals by PPARδ activators results in normalization of metabolism and a reduction of body bat. PPARδ also can increase fat cells when on a high-fat diet by stimulating preadipocyte proliferation and by controlling the induction of PPAR gamma [3].

The nuclear receptor increases the fatty acid burning capacities of muscle and fat tissue by controlling the expression of genes involved in fatty acid uptake, β-oxidation, and energy uncoupling [3].

PPAR delta increases the production of PGC-1a and TGF-beta [12].

PPAR delta potentiates PPAR gamma fat cell production [13].

PPARδ increases FGF-21 [14].

Well described target genes of PPARδ include PDK4, ANGPTL4, PLIN2, and CD36.

PPAR Delta SNPs: rs2016520 T294C

Check out Selfdecode to see if you have these genes.

  1. RS1053049 (PPARD) CC
  2. RS1883322 (PPARD) CC
  3. RS2016520 (PPARD) CT
  4. RS2076167 (PPARD) CC
  5. RS2076169 (PPARD) AA
  6. RS2267668 (PPARD) AG
  7. RS6922548 (PPARD) AG

How to Increase PPAR delta

If you want to interpret your genes and see how they affect your PPAR Delta, you can upload them into SelfDecode.

SelfDecode is a sister company of SelfHacked. The proceeds from your purchase of this product are reinvested into our research and development, in order to serve you better. Thank you for your support.

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


1 Star2 Stars3 Stars4 Stars5 Stars
(9 votes, average: 4.00 out of 5)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published. Required fields are marked *

Related Articles View All