Evidence Based This post has 68 references

PON1 Detox Pesticides Inflammation & Antioxidant

Written by Joe Cohen, BS | Reviewed by Nattha Wannissorn, PhD (Molecular Genetics) | Last updated:

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Are you dealing with oxidative stress? Do you have a problem detoxifying from drugs, supplements or chemicals? Suffer from bacterial infections? Have heart disease? Autism?

PON1 is implicated in all of these. Read on…

The Benefits of PON1


PON1 is responsible for detoxifying organophosphate pesticides and nerve gasses.

It detoxifies lactones (such as statins), glucuronide drugs, thiolactones, aryl esters, cyclic carbonates, estrogens and lipid peroxides (oxidized lipids) [1].

PON1 also protects against bacterial infection by destroying the bacterial signaling molecules that cause gram-negative bacteria to invade human tissue and form colonies. Thus PON1 contributes to the bodies innate immunity [1].

PON1 (paraoxonase 1) is a major anti-atherosclerotic component of HDL. PON1 is transported by HDL, which is one significant reason (if not the only reason) why having higher HDL is protective against heart disease.

It protects against the induction of inflammatory responses in artery wall cells by destroying biologically active lipids in oxidized LDL [2].

Oxidized-fats and cholesterol are the major cause of inflammation and are responsible for the initiation and propagation of several inflammatory diseases including heart disease and stroke, diabetes, liver and kidney diseases, arthritis, eye diseases (macular degeneration), cancer and HIV infection [1].

Because of its ability to destroy oxidized-lipids, PON1 appears to play some role in all these diseases. However, the greatest research interest has been the role of PON1 in heart disease, because of its ability to remove harmful oxidized-lipids [1].

PON1 has a role in healthy aging [1].

People with Autism have lower PON1 activity (arylesterase activity) [3].

PON1 increases SIRT1 [4].

How to Increase PON1


Activating PPAR gamma increases the synthesis and release of PON1 from the liver [5].

Other ways to increase PON1:




What Inhibits PON1

Omega-6’s such as linolenic acid and arachidonic acid decrease PON1 [14].

Low-grade inflammation will decrease PON1, so you should fix general inflammation [1].

PON1 in human blood is inactivated by oxidized LDL and preserved by antioxidants [1], so taking care of oxidative stress, in general, is a good idea.

Bile acids inhibit PON1 via FXR activation [68].

PON1 Genetics

If you want to interpret your genes, you should use SelfDecode. These are SNPs in the PON1 gene.

  1. RS4242382 (PON1)
  2. RS662 (PON1)
  3. RS854555 (PON1)
  4. RS854571 (PON1)

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About the Author

Joe Cohen, BS

Joe Cohen, BS

As a kid, Joe suffered from inflammation, brain fog, fatigue, digestive problems, mood and other issues that were poorly understood in both conventional and alternative medicine. Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers. Joe is a thriving entrepreneur, author and speaker. He is the CEO and founder of SelfDecode. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.


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