Evidence Based This post has 68 references

PON1 Detox Pesticides Inflammation & Antioxidant

Written by Joe Cohen, BS | Last updated:

Are you dealing with oxidative stress? Do you have a problem detoxifying from drugs, supplements or chemicals? Suffer from bacterial infections? Have heart disease? Autism?

PON1 is implicated in all of these. Read on…

The Benefits of PON1


PON1 is responsible for detoxifying organophosphate pesticides and nerve gasses.

It detoxifies lactones (such as statins), glucuronide drugs, thiolactones, aryl esters, cyclic carbonates, estrogens and lipid peroxides (oxidized lipids) [1].

PON1 also protects against bacterial infection by destroying the bacterial signaling molecules that cause gram-negative bacteria to invade human tissue and form colonies. Thus PON1 contributes to the bodies innate immunity [1].

PON1 (paraoxonase 1) is a major anti-atherosclerotic component of HDL. PON1 is transported by HDL, which is one significant reason (if not the only reason) why having higher HDL is protective against heart disease.

It protects against the induction of inflammatory responses in artery wall cells by destroying biologically active lipids in oxidized LDL [2].

Oxidized-fats and cholesterol are the major cause of inflammation and are responsible for the initiation and propagation of several inflammatory diseases including heart disease and stroke, diabetes, liver and kidney diseases, arthritis, eye diseases (macular degeneration), cancer and HIV infection [1].

Because of its ability to destroy oxidized-lipids, PON1 appears to play some role in all these diseases. However, the greatest research interest has been the role of PON1 in heart disease, because of its ability to remove harmful oxidized-lipids [1].

PON1 has a role in healthy aging [1].

People with Autism have lower PON1 activity (arylesterase activity) [3].

PON1 increases SIRT1 [4].

How to Increase PON1


Activating PPAR gamma increases the synthesis and release of PON1 from the liver [5].

Other ways to increase PON1:




What Inhibits PON1

Omega-6’s such as linolenic acid and arachidonic acid decrease PON1 [14].

Low-grade inflammation will decrease PON1, so you should fix general inflammation [1].

PON1 in human blood is inactivated by oxidized LDL and preserved by antioxidants [1], so taking care of oxidative stress, in general, is a good idea.

Bile acids inhibit PON1 via FXR activation [68].

PON1 Genetics

If you want to interpret your genes, you should use SelfDecode. These are SNPs in the PON1 gene.

  1. RS4242382 (PON1)
  2. RS662 (PON1)
  3. RS854555 (PON1)
  4. RS854571 (PON1)

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About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


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