Cannabinoid System, CNR1 Gene & Mood

Written by Joe Cohen, BS | Last updated:
CBD Oil Side Effects

People often ask me which genes I think are the most important?

That could change based on the individual, but the gene that I personally pay a lot of attention to is the main cannabinoid receptor gene (CNR1).

This is the receptor that is activated by cannabis and our internal cannabinoids.

The cannabinoid system has been called the control panel of the human body.

For this reason, I had our team write a report that focused on this gene, which is the most important in the cannabinoid system.

The receptor is concentrated in the brain and gut.

And if you’ve got bad genetic variants, you’ll likely be looking at a whole host of problems:

  • Anxiety
  • Depressed moods
  • Brain fog
  • Food sensitivities
  • Weight balance
  • And many other issues!

There’s one main SNP (rs1049353) in the CNR1 gene that I’ve actually named the “lectin sensitive gene” because this SNP has a big influence on how likely someone is to have food sensitivities.

This SNP is also a HUGE contributor to brain fog if you’ve got the bad variants.

Plus, the endocannabinoid system is crucial in controlling stress and emotions. You need an active CNR1 gene in order to achieve the right balance of neurotransmitters in your brain and to keep your limbic system balanced.

I could keep going on, but I think you’re probably starting to realize how important this gene is. There are very few genes that I think are extremely important on their own, but the CNR1 gene is one of them.

That’s why we’ve created an entire SelfDecode DNA Report to look at the 12 SNPs in the CNR1 gene and tell you how likely you might be to have reduced CNR1 activity levels.

Even better, we aren’t just going to tell you if you’ve got a potentially underactive cannabinoid system, we’re going to give you 10+ personalized and prioritized supplement, diet and lifestyle recommendations on how to increase your CNR1 activity levels.

P.S. Did you know that SelfDecode is the only DNA health report service that tells you why we make each recommendation? We want to be sure that you know why we’re suggesting a specific supplement, diet or lifestyle change, so we always provide references that you can check to see where our science is coming from!

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


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