Gut Inflammation, Curcumin & The Root of All Evil

Written by Joe Cohen, BS | Last updated:

What’s the true root of all evil? Not money…


Seriously. Almost every health problem I’ve battled comes down to it –

Brain fog, food sensitivities, stomach problems, poor motivation…

All my autoimmune issues started from the gut because I have so many genes causing gut inflammation. Knowing this made it easier to improve my gut and overall health.

Out of the 42,930 genetic variants linked to gut inflammation, one gene in particular was causing me trouble.

The gene that has cursed my gut

If inflammation is the true root of all evil, then NF-kB is its best evil weapon.

NF-kB is an important inflammatory protein. In response to viruses, bacteria and UV radiation, it increases the transcription of genes controlling inflammation.

The NFKB1 gene encodes this protein. Many variants are linked to gut inflammation. This is because carriers of these variants have increased NF-kB levels, and therefore, increased inflammation.

Unfortunately, I have one of these “bad” variants, giving me a high genetic risk for gut inflammation.

But it isn’t all bad. Knowing my gut problems were due to genetics has made it much easier to solve the root of the issue.

I started with my NFKB1 gene, because that’s the most obvious link between my DNA and gut inflammation.

My Gut Inflammation Report recommended I start supplementing with Curcumin.

Curcumin is a compound found in turmeric, a yellow spice from India. Curcumin is helpful for gut health, but it’s also used for joint pain, hay fever, mood and blood pressure.

The compound works by inhibiting NF-kB, which reduces inflammation. Curcumin also has an unrivaled safety profile which made it an easy choice to add to my regimen.

I immediately noticed reduced gut inflammation. As my gut health improved over time, I saw my other health issues begin to improve.

Curcumin has become a regular part of my health routine. I take 2 capsules every morning. I even started taking a bioavailable curcumin that crosses the brain barrier and improves brain health.

But curcumin isn’t for everybody

Just because curcumin works for me doesn’t mean it’ll work for you. That’s not how the human body operates. It’s not one-size-fits-all.

I started supplementing curcumin because there is scientific evidence of its effectiveness on people with my NFKB1 gene variant.

But most people don’t have my NFKB1 gene variant. And for those people, curcumin may not be the best supplement for them.

That’s why it’s important to analyze your genes to understand which steps are best for your unique health situation.

This gene-based approach to health is easy. I just clicked “generate report” on SelfDecode and got prioritized recommendations based on my DNA.

So if you’re experiencing Gut Inflammation, check your report to see which gene variants you should target.

SelfDecode’s Gut Inflammation Report analyzes 42,930 gene variants linked to IBD. It’s the most comprehensive genetic report science can currently offer.

P.S. If you don’t have any problems with gut inflammation, we have 19+ other DNA reports (anxiety, mood, fatigue, pain, to name a few)…

PLUS we release a new DNA wellness report every single week. Get access to every report, past and future.

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


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