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Improving Cognitive Performance By Inhibiting Nogo-A

Written by Joe Cohen, BS | Last updated:

Learn how to increase brain plasticity and learn new things faster. This post explains how to inhibit the gene Nogo-A which results in an increased ability to create new neuronal connections.

Nogo-A is Critical In Controlling Plasticity

The Nogo Receptor 1 gene (also called Reticulon 4) is required to suppress high levels of plasticity in the adolescent brain and create relatively low levels of plasticity in adulthood. In mice without this gene, juvenile levels of brain plasticity persist throughout adulthood. When researchers blocked the function of this gene in old mice, they reset the old brain to adolescent levels of plasticity [1].

Researchers found that adult mice lacking Nogo Receptor recovered from injury as quickly as adolescent mice and mastered new, complex motor tasks more quickly than adults with the receptor [1].

Researchers also showed that Nogo Receptor slows the loss of memories. Mice without the Nogo receptor lost stressful memories more quickly, suggesting that manipulating the receptor could help treat post-traumatic stress disorder [2].

Blocking Nogo can help:

  • Boost signal strength between the synapses, which is central to the brain’s ability to rewire [3].
  • Multiple Sclerosis [4]
  • Alzheimer’s [4]
  • ALS [4]


After reading the ScienceDaily article, I set out to find a compound that can inhibit Nogo-A. I was led to a forum that suggested two Chinese herbal mixtures, a drug called fasudil (which I have no interest in taking), and a ridiculous dose of vitamin E as inhibitors of Nogo-A.

Both Chinese formulations have around a dozen herbs, but after a quick scan, I guessed that the culprit for the Nogo-A inhibition is catalpol, which is found in the herb Rehmannia. I found a somewhat shady study that confirmed that catalpol inhibited Nogo-A [5].

Rehmannia is also used in Chinese herbology for recovery of stroke and traumatic brain injuries, which further strengthens that Catalpol is the active ingredient.

I also found a study that showed catalpol enhanced cortical neuron axonal growth in rats [6], an effect that could be attributed to Nogo-A inhibition.

Also, Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats [7].

Personal Experiences with Rehmannia

The first time I tried it I took a relatively large dose of about 35 grams because I liked the taste. The suggested dose is about 5 grams when used chronically, but I only realized that posthoc.

I stupidly took it at night and my brain felt like it was on turbo boost and I wasn’t able to sleep much that night, even though I had already been sleep-deprived from the previous nights.

I experienced to a small degree the expected digestive heaviness that is attributed to it in TCM.

I noticed that it increases cortisol (which is supported by animal studies) and it has a distinct cognitive enhancing effect, different than anything else I’ve tried.

However, this substance isn’t for me. I get flatulence whenever I try it. If I take it at night it keeps me up and if I take it in the day I get fatigued – likely because it has lectins and I’m lectin sensitive.

I’d recommend it to those that aren’t lectin sensitive.

Nogo-A Inhibitors Go Well With

Rehmannia goes well Astragalus and is especially effective for wound repair.

Buy Nogo-A Inhibitors (Rehmannia)

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About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


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