Fear & Anxiety: 3 Genes To Look At

Written by Joe Cohen, BS | Last updated:

What if you could go through life without fear and anxiety?

How would your life look?

Oftentimes, these feelings seep into every aspect of your life and stop you in your tracks.

But did you know that this feeling fear and anxiety are a result of biochemical changes?

Not only that, but there’s many different genes and biological sources that create and make it worse.

When I was suffering from anxiety and depression, I would use Dr. Google and come across so many articles on how to “fix your anxiety” and I would literally try them all.

I was taking lemon balm, chamomile, passionflower and theanine because they were some of the best supplements for anxiety – but they didn’t help me at all.

You name it, I tried it (and wasted tons of money doing so.) I would literally have to take every single supplement I could get my hands on, but even then it wasn’t always clear what was working and what wasn’t. Sometimes you have to take them for an extended period of time to see if something works.

Anxiety response is affected by so many things, like oxytocin, GABA, BDNF, glutamate, serotonin, and cortisol.

So how do you discover what you’re susceptible to?

The answer lies in your genes.

It wasn’t until I started looking at my genes that my life completely changed. I managed to pinpoint exactly what my body needed, and found the supplements that effectively worked on me. My anxiety completely went away, and this process helped me save money as well.

Not only did this work for me, but I use the same approach to help my partners and friends.

By looking at your genes, you can discover diet, supplement, and lifestyle changes that can decrease your anxiety, improve your mood, and completely change your life.

Oxytocin, OXTR Gene and Your Amygdala

When you feel threatened and afraid, a part of your brain – called the amygdala – automatically activates the fight-or-flight response. Oxytocin (or the love hormone) decreases the sensitivity your amygdala has to signs of threat.

If you carry the negative variant of the OXTR gene, your oxytocin levels will decrease. This means you will be more sensitive to smaller “signs of threat,” which can cause anxiety to occur on things like a short social interaction.

If you do carry the negative variant, there’s a specific natural, plant supplement that can increase your OXTR gene activity, improve your oxytocin, and decrease your anxiety!

PITX2 Gene and GABA

The PITX2 gene enables the production of GABA, which is an extremely important neurotransmitter that produces a calming effect when it attaches to proteins in your brain.

The negative variant actually decreases GABA production, which is a hallmark in plenty of different anxiety disorders.

There’s a specific tea that targets the bad gene variant by helping to balance the GABA levels in your brain.

BDNF Gene and Cortisol

The BDNF gene creates BDNF (Brain-derived neurotrophic factor), which prevents the excess release of the stress hormone cortisol.

The bad variant of this gene actually has a number of negative effects. Decreased BDNF causes an increase in cortisol, which results in higher anxiety levels. On top of that, excess cortisol damages the hippocampus, which results in more stress-related hormones running rampant in the brain.

That’s why it’s extremely important to understand what variant you carry, so that you can implement changes that will counteract any negative effects.

How To Check All Of Your Anxiety Genes

We often neglect taking care of our mental health. But If you haven’t made it a priority, now is the perfect time.

With our scientific research, genetic data, and AI technology, there’s an easy way to check ALL of the genes related to your anxiety, and find out what the most important changes are for your body.

With the SelfDecode Anxiety DNA report, we look at the 3 genes listed above, along with 25 other genes related to anxiety.

Plus, it’s so easy to start seeing results right away. We give you a prioritized list of personalized diet, lifestyle, and supplement recommendations that will work better than anything else you’ve tried because they’re based on your body.

These aren’t generic recommendations, they are specific to your genes.

When you sign up for SelfDecode, you’ll receive your personalized Anxiety DNA Report, plus:

  • SelfDecode Personalized Genetics Blog – 400 personalized genetics articles help you get to the root cause of your health issues using your unique DNA.
  • Personalized DNA Wellness Reports – more in-depth genetic reports on topics like trauma, mood, and sleep that provide you with recommendations specific for your body, so that you can solve any health problem you’re experiencing.
  • ALL SelfHacked articles (ad-free!) – Read from over 1500 science-based health articles that go in-depth on the benefits of natural supplement and lifestyle health changes, so you can understand exactly what you’re taking to optimize your mood.
  • Lab Test Analyzer tool – Upload your lab results, look at markers related to mood, and discover how you can get your levels to the optimal range. We analyze over 1000 markers and will add any that we don’t have!

and so much more!

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission of empowering people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time.


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