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My Regimen to Improve Mood

Written by Joe Cohen, BS | Last updated:

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How to Read My Regimen

To save space, I won’t detail exactly what it is doing, but I just bring down the general area that it improves. So if you see “mood”, it means that said substance or approach is improving my mood.

I recommend this post: ​​My Regimen of 100 Supplements

What I Take To Improve Mood


  1. Sunlight
  2. Sleep
  3. Water (3.5L/day – a bit less than 1 gallon) (Mood, cognition, Lowers: hsCRP, WBC, Glucose, Sodium, Potassium, Calcium, Phosphorus, Hb, Hct, RBC, Urea, Uric acid, IgG+)
  4. Exercise: Walking, Pushups & Yoga



Why I take it: 

  1. Mood stability (Serotonin)
  2. Sleep (REM)
  3. T3?


Why I take it:

  • Mood (GABA, ATP/energy, Serotonin, Dopamine, Acetylcholine, Antioxidant) – Hippocampus
  • Immunity
  • Cardiovascular (Cholesterol)
  • Mitochondria
  • Gut
  • Cognitive function (Myelin)
  • Glucose
  • Ergogenic
  • Kidney (Urea [1])

Resistant Starch (Butyrate)

Why I take it:

  1. Food tolerance
  2. Mood (HDACi, GSK3bi, Serotonin, BDNF, CREB, GDNF, NGF, GABA, Dopamine, Norepinephrine, Endorphins, Antiinflammatory, Antioxidant) – Cerebral Cortex, Hippocampus, Prefrontal Cortex
  3. Cognitive function
  4. Wakefulness
  5. Energy (Mitochondria)
  6. Kidney2, GPR109a, HDACi, Urea [3], Indoxyl Sulfate, p-cresol)
  7. Cancer (HDACi)
  8. Gut (HCA2)
  9. Inflammation
  10. Cardiovascular health (LDL, APOB, TMAO)
  11. Fat loss
  12. Glucose control
  13. Longevity
  14. Muscle


Why I take it:

  • Mood (Serotonin, Norepinephrine, NPY, Endorphins, DRD1, DRD2, MAOAi, MAOBi, 5HT1A, Acetylcholine, BDNF, NGF, ATP/energy, NO pathway inhibition, Antiinflammatory, Antioxidant) – HPA axis, Hippocampus, Prefrontal Cortex
  • Wakefuless
  • Immunity
  • Longevity
  • Reaction time [R]
  • Kidney


Why I take it:

  • Mood (BDNF, CREB, GDNF, Serotonin, GSK3bi, NMDA antagonism, AMPA/Kainate activation, Antioxidant)
  • Longevity
  • Sleep
  • Cognitive function (Myelin)
  • Kidney (low doses)
  • Bone


Why I take it:

Green Tea Extract/EGCG

Why I take it:

  • Mood (Serotonin, BDNF, Dopamine, MAOBi)
  • Cognitive function (Attention, Memory, Working Memory)
  • Cardiovascular (APOB, LDL, HRV)
  • Longevity
  • Sleep
  • Flu prevention
  • Bladder health
  • Hair (DHT(-))
  • Skin health
  • Diuretic
  • Muscle
  • Inflammation (STAT3(-))
  • Cancer
  • Kidney health (Urate)


Why I take it:

  • Mood (GSK3bi, BDNF, MAOBi, Serotonin, Dopamine, 5HT1A, 5HT2C, NMDA antagonism, Cannabinoid receptor 1, Antiinflammatory, Antioxidant)
  • Inflammation (STAT3i)
  • Cardiovascular health (LDL, APOB, LPa)
  • Cognitive function (Working Memory)
  • Antimicrobial, Antifungal
  • Cancer
  • Hair (DHTi)
  • Gut health
  • Kidney (p-cresol,)


Why I take it:

  • Mood (BDNF, GSK3Bi, Reducing glutamate, NMDA antagonism)
  • Immunity & Infections, Common Cold
  • Cardiovascular (LDL)
  • Cognitive function (attention, reasoning)
  • Glucose balance
  • Skin health
  • Inflammation (STAT3)
  • Gut health
  • Energy/Physical performance
  • Testosterone
  • Thyroid (T3 (+))
  • Vision
  • Bone health
  • Hair
  • Kidney health
  • Tinnitus
  • Oral health/Gums
  • Sleep quality and duration


Why I take it:

  • Mood (Dopamine, Serotonin)
  • Homocysteine & Methylation, Methionine
  • Cognitive (Myelin)
  • HRV
  • Kidney health (Uric acid, Urea)
  • Glucose
  • Muscle & Exercise Performance

Vitamin B12

Why I take it:


Why I take it:


Why I take it:

B6: Pyridoxine 

Why I take it:

Vitamin C

Why I take it:

  • Mood (BH4, Dopamine, BDNF, Norepinephrine, GABAA receptor, NMDA antagonism, GSK3bi, Na+/P+ channels, NO pathway inhibition, Antioxidant)
  • Cognitive function (Reaction time, Myelin
  • Cardiovascular (APOB, LDL?)
  • Sleep quality
  • Kidney Health (Urate, Phosphorous
  • Antifungal, Mitochondria, 
  • Skin (Collagen)
  • Bone
  • Immunity
  • Inflammation (hsCRP)
  • Thyroid (Thyroid hormones animals)


Why I take it:

  • Mood (Serotonin, CREB, cAMP, BDNF, Acetylcholine, Norepinephrine, Dopamine production/transport, MAOAi, 5HT1A, 5HT2C, IP3, Antioxidant)
  • Cognition (Reaction time, Processing speed, Memory, Attention, Working Memory
  • Hair
  • Longevity
  • Kidney health
  • Thyroid (T4+T3 – mice)


Why I take it:


Why I take it:

  • Mood (Serotonin, GABAA Receptor activation, PDE4i, VMAT2 increase, BDNF, cAMP, CREB, Acetylcholine, Cannabinoid receptor 1, light inhibition of opioid receptors)
  • Cognitive function (Working memory, Long term memory, Wakefulness, Attention)
  • Kidneys
  • Inflammation


Why I take it:

  • Mood (Serotonin, BDNF, CREB, GABAA Receptor activation, Acetylcholine, NMDA antagonism, Beta2 adrenergic activation, light inhibition of opioid receptors)
  • Cardiovascular (LDL, Blood pressure)
  • Cognitive function (Reaction time)
  • Vision/Eye health
  • Libido
  • Immunity (increases WBCs)
  • Physical performance

About the Author

Joe Cohen, BS

Joe Cohen, BS

As a kid, Joe suffered from inflammation, brain fog, fatigue, digestive problems, mood and other issues that were poorly understood in both conventional and alternative medicine. Frustrated by the lack of good information and tools, Joe decided to embark on a journey of self-experimentation and self-learning to improve his health--something that has since become known as “biohacking”. With thousands of experiments and pubmed articles under his belt, Joe founded SelfHacked, the resource that was missing when he needed it. SelfHacked now gets millions of monthly readers. Joe is a thriving entrepreneur, author and speaker. He is the CEO and founder of SelfDecode. His mission is to help people gain access to the most up-to-date, unbiased, and science-based ways to optimize their health.


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