How to Read My Regimen

To save space, I won’t detail exactly what it is doing, but I just bring down the general area that it improves. So if you see “mood”, it means that said substance or approach is improving my mood.

I recommend this post: ​​My Regimen of 100 Supplements

What I Take To Improve Mood

Lifestyle

1. Sunlight
2. Sleep
3. Water (3.5L/day – a bit less than 1 gallon) (Mood, cognition, Lowers: hsCRP, WBC, Glucose, Sodium, Potassium, Calcium, Phosphorus, Hb, Hct, RBC, Urea, Uric acid, IgG+)
4. Exercise: Walking, Pushups & Yoga

Supplements

5HTP

Why I take it: 

1. Mood stability (Serotonin)
2. Sleep (REM)
3. T3?

Thiamine

Why I take it:

• Mood (GABA, ATP/energy, Serotonin, Dopamine, Acetylcholine, Antioxidant) – Hippocampus
• Immunity
• Cardiovascular (Cholesterol)
• Mitochondria
• Gut
• Cognitive function (Myelin)
• Glucose
• Ergogenic
• Kidney (Urea [1])

Resistant Starch (Butyrate)

Why I take it:

1. Food tolerance
2. Mood (HDACi, GSK3bi, Serotonin, BDNF, CREB, GDNF, NGF, GABA, Dopamine, Norepinephrine, Endorphins, Antiinflammatory, Antioxidant) – Cerebral Cortex, Hippocampus, Prefrontal Cortex
3. Cognitive function
4. Wakefulness
5. Energy (Mitochondria)
6. Kidney –2, GPR109a, HDACi, Urea [3], Indoxyl Sulfate, p-cresol)
7. Cancer (HDACi)
8. Gut (HCA₂)
9. Inflammation
10. Cardiovascular health (LDL, APOB, TMAO)
11. Fat loss
12. Glucose control
13. Longevity
14. Muscle

Rhodiola 

Why I take it:

• Mood (Serotonin, Norepinephrine, NPY, Endorphins, DRD1, DRD2, MAOAi, MAOBi, 5HT1A, Acetylcholine, BDNF, NGF, ATP/energy, NO pathway inhibition, Antiinflammatory, Antioxidant) – HPA axis, Hippocampus, Prefrontal Cortex
• Wakefuless
• Immunity
• Longevity
• Reaction time [R]
• Kidney

Lithium

Why I take it:

• Mood (BDNF, CREB, GDNF, Serotonin, GSK3bi, NMDA antagonism, AMPA/Kainate activation, Antioxidant)
• Longevity
• Sleep
• Cognitive function (Myelin)
• Kidney (low doses)
• Bone

Methylfolate 

Why I take it:

• Mood (Serotonin, Dopamine, Norepinephrine, SAMe)
• Homocysteine, Methylation
• Cholesterol
• Fasting
• Muscle
• Myelin
• Kidney – not low or high folate levels, prolonged survival in kidney disease
• TSH
• Adequate intake: verbal fluency, processing speed, sustained attention, and working memory

Green Tea Extract/EGCG

Why I take it:

• Mood (Serotonin, BDNF, Dopamine, MAOBi)
• Cognitive function (Attention, Memory, Working Memory)
• Cardiovascular (APOB, LDL, HRV)
• Longevity
• Sleep
• Flu prevention
• Bladder health
• Hair (DHT(-))
• Skin health
• Diuretic
• Muscle
• Inflammation (STAT3(-))
• Cancer
• Kidney health (Urate)

Curcumin

Why I take it:

• Mood (GSK3bi, BDNF, MAOBi, Serotonin, Dopamine, 5HT1A, 5HT2C, NMDA antagonism, Cannabinoid receptor 1, Antiinflammatory, Antioxidant)
• Inflammation (STAT3i)
• Cardiovascular health (LDL, APOB, LPa)
• Cognitive function (Working Memory)
• Antimicrobial, Antifungal
• Cancer
• Hair (DHTi)
• Gut health
• Kidney (p-cresol,)

Zinc

Why I take it:

• Mood (BDNF, GSK3Bi, Reducing glutamate, NMDA antagonism)
• Immunity & Infections, Common Cold
• Cardiovascular (LDL)
• Cognitive function (attention, reasoning)
• Glucose balance
• Skin health
• Inflammation (STAT3)
• Gut health
• Energy/Physical performance
• Testosterone
• Thyroid (T3 (+))
• Vision
• Bone health
• Hair
• Kidney health
• Tinnitus
• Oral health/Gums
• Sleep quality and duration

TMG/Betaine

Why I take it:

• Mood (Dopamine, Serotonin)
• Homocysteine & Methylation, Methionine
• Cognitive (Myelin)
• HRV
• Kidney health (Uric acid, Urea)
• Glucose
• Muscle & Exercise Performance

Vitamin B12

Why I take it:

• Mood (Dopamine, Serotonin, Norepinephrine, SAMe)
• Energy/mitochondria
• Cardiovascular (reduces LDL, Homocysteine)
• Cognitive function (increases Myelin, Adequate intake: verbal fluency, processing speed, sustained attention, and working memory) 
• Lowers Homocysteine, increases methionine, converts SAH to SAM

Ashwagandha

Why I take it:

• Mood (Serotonin, GABAA Receptor activation)
• Cognitive function (Reaction time, Myelin, Executive function, Attention, Spacial processing)
• Sleep quality
• Longevity
• Testosterone & Libido
• Muscle
• Cardiovascular (LDL, Heart rate)
• Glucose balance
• Inflammation (CRP)
• Exercise performance (Power)
• Thyroid (TSH, T4, T3)

Myoinositol

Why I take it:

• Mood (Serotonin, Dopamine, IP3/DAG, 5HT2A)
• Sleep
• Cardiovascular (LDL)
• Glucose tolerance
• Mitochondria
• Longevity
• Kidney
• Thyroid hormones (T4, T3)

B6: Pyridoxine 

Why I take it:

• Mood (Increasing GABA, Reducing Glutamate, Dopamine, Serotonin, Norepinephrine)
• Sleep (dreaming) 
• Cardiovascular health (Homocysteine -> Cysteine)
• Kidney (AGEs), Prolactin)
• Inflammation

Vitamin C

Why I take it:

• Mood (BH4, Dopamine, BDNF, Norepinephrine, GABAA receptor, NMDA antagonism, GSK3bi, Na+/P+ channels, NO pathway inhibition, Antioxidant)
• Cognitive function (Reaction time, Myelin
• Cardiovascular (APOB, LDL?)
• Sleep quality
• Kidney Health (Urate, Phosphorous) 
• Antifungal, Mitochondria, 
• Skin (Collagen)
• Bone
• Immunity
• Inflammation (hsCRP)
• Thyroid (Thyroid hormones animals)

Bacopa

Why I take it:

• Mood (Serotonin, CREB, cAMP, BDNF, Acetylcholine, Norepinephrine, Dopamine production/transport, MAOAi, 5HT1A, 5HT2C, IP3, Antioxidant)
• Cognition (Reaction time, Processing speed, Memory, Attention, Working Memory) 
• Hair
• Longevity
• Kidney health
• Thyroid (T4+T3 – mice)

L-theanine

Why I take it:

• Mood (Dopamine production/transport, DRD1, BDNF, GABA, Norepinephrine, Serotonin, AMPA activation, NMDA receptor activation, Antioxidant)
• Cognitive function (Reaction time, Attention)
• Longevity
• Flu, HRV, 
• Sleep quality (REM) 
• Kidney health

Zembrin

Why I take it:

• Mood (Serotonin, GABAA Receptor activation, PDE4i, VMAT2 increase, BDNF, cAMP, CREB, Acetylcholine, Cannabinoid receptor 1, light inhibition of opioid receptors)
• Cognitive function (Working memory, Long term memory, Wakefulness, Attention)
• Kidneys
• Inflammation

Saffron

Why I take it:

• Mood (Serotonin, BDNF, CREB, GABAA Receptor activation, Acetylcholine, NMDA antagonism, Beta2 adrenergic activation, light inhibition of opioid receptors)
• Cardiovascular (LDL, Blood pressure)
• Cognitive function (Reaction time)
• Vision/Eye health
• Libido
• Immunity (increases WBCs)
• Physical performance