Joe Cohen's Regimen of 170 Supplements (Updated Dec 05 2024)

Created for Me

Let me start by saying that this is MY personal health regimen. It was made for me, and only me. I created it by using SelfDecode to look at my genetic predispositions, experimenting with the recommendations, and doing my own research and tests to find what works best for my body.

I am clearly pushing the boundaries on what is normal, and perhaps even what is optimal. But I like to push the boundaries.

I always suggest that you follow a health regimen personalized for you. For that, I recommend SelfDecode, which tells you what the top recommended lifestyle and supplements are for your unique DNA.

For most people, I would recommend 5-10 supplements or a formula that contains the necessary ingredients. However, this is my profession and I’ve been taking and researching dietary supplements for the past 20 years, so I am quite more advanced in this area.

Admittedly, my regimen is pretty intense. I do take around 150 different supplemental ingredients a day, in the form of shakes and pills. Over the long term, I might cut back on the number of supplements. It will depend on what it takes to get all my labs and my personal goals in the optimal range – and if I get any negative side effects from taking so many supplements.

So far, my rate of aging is the slowest in the world (0.63) and almost all of my biomarkers are optimized. As long as my results are good, I will continue this approach.

This approach works better than Bryan Johnson’s Blueprint.

Criteria to Make It In My Regimen

To get in my regimen, it has to comply with at least 1/6 and usually all of the requirements here:

Placebo controlled trial showing effectiveness for one of my goals
Noticeable, positive effect in a mega-dosing experiment
Noticeable & positive change in a biomarker I want to improve
Benefit more than 1 goal of mine i.e. can’t just benefit one specific thing (Pleiotropic)
No significantly harmful side effects or long-term risks
Good personal fit – Improves biochemical or genetic pathway that is of particular interest to me

I want to be clear that I am not recommending megadosing experiments to the lay user, and that I am aware they do contain some risk. SelfDecode was created so that you don’t have to mega dose and you will have the knowledge about what to do to improve your health the most.

My Health Goals

In order for a supplement or lifestyle habit to be included in my regimen, it must go toward achieving some of my health goals:

Longevity – live to 120 without disease.
Health Span & Disease prevention (Cardiovascular disease, Cancer, Dementia, Kidney Disease, etc…) – prevent disease until 100.
Mood (high baseline happiness, no anxieties or fears, mentally & stress resilient, stable mood)
Energy, Wakefulness, Stamina, Motivation, Drive
Cognitive function (Focus/Attention, Working memory, Information processing, Verbal fluency, Long Term Memory, Creativity)
Immunity – to not get sick…(preventing infections, functioning well during infections, getting over them quickly)
Beauty: Hair, Skin, Nails, Teeth
Body composition (high muscle mass, low fat mass, 6 pack, etc..) & Strength
Great Sleep every night
Gut health
Quick recovery
No Pain (no aches or pains, rapid recovery from exercise, injuries, etc..)
Metabolic Health (never feeling hungry, while staying lean)
Empathy, Extraversion (when desired) & Social Intelligence

Tracking my Labs

It’s very important to track labs when taking supplements to make sure that you not only feel better but also things are working better “under the hood”.

A lot of supplements I take are there to enhance my lab values.

See this post: Measuring My Health: Lab Tests & Data Points I Track

The Supplements I Take

Dosage is total per day, often split it up.

Jos Resistant Starch (30g fiber) – Amazon
Collagen (10g) – Iherb
Whey (100g) – Iherb
Glutamine (10g) – Iherb | Amazon
AAKG (1g) – Iherb
Lysine (5g) – Iherb | Amazon
Creatine (6g) – Iherb | Amazon
TMG (5g) – Iherb | Amazon
Glycine (14g) – Iherb | Amazon
Leucine (4g) – Iherb | Amazon
L Serine (3g) – Iherb
Arginine (1g) – Iherb
Histidine (2g) – Iherb | Amazon
Beta Alanine (3g) – Iherb
HMB (3g) – Iherb
Citrulline (12g) – Iherb | Amazon
Agmatine (2g) – Iherb | Amazon
Tryptophan (2g) – Iherb | Amazon
NAC (2.4g) – Iherb
Taurine (3g) – Iherb | Amazon
L Threonine (1.5g) – Iherb
Valine (1g) – Amazon
L Norvaline (300mg) – Amazon
Hyaluronic Acid (360mg) – Iherb
Allulose (10g) – Iherb
Lecithin (5g) – Iherb
Vitamin K2 (1.5mg) – Iherb
Molybdenum (100mcg) – Iherb
Green Tea (2.5g) – Iherb
Yerba Mate Tea (5g) – Iherb
Pregnenolone (30mg) – Iherb | Amazon
Allithiamine (50mg) – Iherb | Amazon
Thiamine Diphosphate/Cocarboxylase (13mg) – Iherb
Riboflavin (50mg) – Iherb
Pantethine (50mg) – Iherb
Niacin (200mg) – Iherb
B6/P5P (75mg) – Iherb | Amazon
Biotin (3mg) – Iherb
Methylfolate (2mg) – Iherb
B12/Methylcobalamin (100mcg) – Iherb
PABA (50mg) – Iherb
Fish oil/Omega 3 – Iherb
Kelp (1g – 540mcg iodine) – Iherb | Amazon
DHEA (25mg) – Iherb | Amazon
Vitamin C (12g/day) – Iherb
Ergothioneine (10mg) + Oyster mushroom, Shiitake, Lion’s Mane – Iherb | Amazon
NMN (1g) – Iherb
Longvida Curcumin (1g) – Iherb | Amazon
Blueberry Extract (500mg) – Iherb or Grapeseed Extract (500mg) – Iherb
Avena Sativa extract (430mg 0.2% isovitexin) – Iherb
Ubiquinol (200mg) – Iherb | Amazon
Tocotrienols (50mg) – Iherb
Shilajit (500mg) – Iherb | Amazon
Ecklonia Cava extract (80:1 106mg) – Iherb | Amazon
Carob (10g) – Iherb
Inositol (4g) – Iherb | Amazon
Chocamine (200mg) – Iherb
Brown Seaweed (Fucoxanthin & Punicic acid) – Iherb
Astragaloside IV (50mg) – Nootropics Depot
Cordyceps (10:1 – 250mg) – Nootropics Depot
Royal Jelly (3:1 – 500mg) – Iherb
Green Tea Extract (400mg GTE – 50% EGCG) – Iherb
Glucosamine Sulfate (1.5g) – Iherb | Amazon
Chlorella (4g) – Iherb | Amazon
Spirulina (3g) – Iherb | Amazon
Magnesium Glycinate – Iherb
Calcium carbonate (1.5g) – Iherb
5HTP (100mg) – Amazon
Rhodiola (400mg) – Amazon
Theanine (100mg) – Amazon
Bacopa (bacognize) (120mg) – Amazon
Ashwagandha Shoden (120mg, 30% Withanolides) – Nootropics Depot
Lithium Orotate (5mg) – Amazon
Honokiol (50mg)
Potassium bicarbonate (1g) – Iherb
Potassium Chloride (4g) – Iherb | Amazon
TUDCA (1g) – Iherb | Amazon
Flax oil – Iherb
Borage oil – Iherb
Astaxanthin (12mg) – Iherb
Sulforaphane (350mg, 10% Sulforaphane) – Iherb | Amazon
Reishi (500mg 8:1) – Nootropics Depot
Uridine Monophosphate (300mg) – Iherb
Black Seed/Thymoquinone (200mg, 10% Thymoquinone) – Nootropics Depot
Fucoidan (300mg 70% Fucoidan) – Iherb
Boron (6mg) – Iherb
Thymus glandular (500mg) – Iherb
Spleen glandular (600mg) – Iherb
Lycopene (15mg) – Iherb
Pepsin (250k FCC)
Pancreatin (11X, 200mg) – Iherb
Bromelain (500mg) X3 – Iherb
Papaya/Papain – Iherb
Melatonin (1mg) – Iherb
Poria (500mg) – Nootropics Depot
Cardamom (2g) – Iherb
Cinnamon (1g) – Iherb
Olive leaf extract (250mg) – Iherb
MSM (6g) – Iherb | Amazon
Beta Hydroxybutyrate (3g) – Iherb
Strontium (80mg) – Iherb
Cognance (Ebelin Lactones) – Nootropics Depot
Sabroxy/Oroxylin A (250mg) – Nootropics Depot
PQQ (20mg) – Iherb | Amazon
Hydroxytyrosol (25mg) – Iherb
MCT Oil (C8,C10) – Iherb
Chromium Picolinate (500mcg) – Iherb
Vanadium (350mcg) – Iherb
Pterostilbene (10mg) – Iherb
Genistein/Daidzein (10mg each) – Iherb
Prescript assist probiotic – Amazon
Spermidine (wheat germ, 5mg) – Iherb
Butyrate (600mg Ca/Mg) – Iherb | Amazon
Tongkat Ali (TestoJack, 300mg) – Iherb
Acetylcarnitine (500mg) – Iherb
Alpha Carotene (800mcg) – Iherb
Trehalose (10g) – Iherb
Selenium (53mcg) – Iherb
Dextrose (10g) – Iherb
Chondroitin Sulfate (600mg) – Iherb
Raw Honey (25g) – Iherb
R Lipoic Acid (200mg) – Iherb
Geranylgeraniol (150mg) – Iherb
Hypothalamus glandular – Amazon
1 Renew Life, Ultimate Flora Adult 50+ Probiotic: 1 B lactis BI-04®, B lactis HN019™, B lactis Bi-07®, Bifidobacterium infantis Bi-26™, Lactobacillus plantarum Lp-115®, Lactobacillus rhamnosus GG, Lactobacillus acidophilus NCFM®, Lactococcus lactis LI-23™, Lactobacillus casei Lc-11®, Lactobacillus paracasei Lpc-37®, Lactobacillus acidophilus La-14®, Lactobacillus brevis Lbr-35™- Iherb
L Reuteri NCIMB 30242 (5 billion CFU) – Iherb
L Plantarum 299v (10B) – Iherb
B Longum BB536 (10B CFU) X2 – Iherb
B Lactis HN019 (10B CFU) X2 – Iherb
L Rhamnosus GG (5B CFU) – Iherb
B Coagulans MTCC 5856 (2B CFU) X2 – Iherb
B Breve M16V – Iherb
Phage: LH01 – Myoviridae; LL5 – Siphoviridae; T4D – Myoviridae; LL12 – Myoviridae – Iherb
Clostridia Butyricum (Pendulum 15M AFU) – Iherb
Advanced Multi-Billion Dophilus® 5 Billion CFU (Lactobacillus acidophilus (LA-5®), Bifidobacterium lactis (BB-12®), Lactobacillus paracasei, (L. CASEI 431®), Lactobacillus rhamnosus (GG LGG®) – Iherb
Modified Citrus Pectin (5g) – Iherb
Forskolin (50mg)
CLA (1g) – Iherb
Garlic Ext (Allicin)
Elderberry
Shiitake
Maitake
Berberine
Astragalus
Lactoferrin
Kombucha
Vitamin A (5000 iu/day)
Fo-Ti
C15
Inulin
FOS
GOS
HMO
PHGG
Arabinogalactan
XOS – Iherb
Ginger – Iherb
Cannabis drops
Bacopa (55% Baccosides) – Iherb
Chamomile (375mg) – Iherb
Emoxypine (125mg) (OTC)
Resveratrol (200mg)
Sceletium Tortuosum/Kanna (50mg) – Iherb | Amazon
American Ginseng (500mg) – Iherb
Arginine (500mg)
Matcha (1g)
Colostrum – Iherb 1X/wk
Activated Charcoal (5g) 1X/wk
Inosine 1X/wk

Rapamycin – 4mg/wk – for longevity
Canagiflozin (125mg) – for blood sugar
Acarbose (50mg X3) – for blood sugar
Low Dose Naltrexone (3.5mg) – for sleep
Trazadone (25mg) – for sleep
Ezetimibe (10mg) – to lower LDL
Bempedoic Acid (180) – to lower LDL
Inclisiran (PCSK9i) – to lower LDL
Ketamine – 30mg, 1X/wk – mood
Psychedelics – 1X/wk (LSD/2CB)

A/B Testing over the long term

Meclizine (25mg) – for sleep & longevity
Thyroid Hormones (100mcg T4, 20mcg T3)
Bromantane (15mg) – taken out temporarily
Teacrine
Alpinia Galanga
Lion’s Mane (8:1 – 500mg) – Nootropics Depot – may have caused fatigue after prolonged use
Celastrus (500mg)
Citrus Bioflavonoids/Bergamot
B Subtilis (AOR 1.2M CFU, DE111 – probiotic duo) X2 – Iherb
Tyrosine (500mg) – Iherb
Apple cider vinegar – Iherb

Taken out OR Intermittent:

L-Carnitine (1g) – TMAO was high
Saffron (15mg) – Iherb | Amazon
Celery seed extract – Iherb – no need for extra mood support
Ox Bile (100mg) – Iherb – no need
Nutritional Yeast (10g) – Iherb – contributed to gas
Psyllium Husk (5g) – Iherb – gas
NADH (20mg) – Nootropics Depot – NAD+ levels are high enough
Krill Oil (1g) – Iherb – no extra benefit over fish oil

Joe Cohen’s Regimen of 170 Supplements (Updated Dec 05 2024)