Joe Cohen's Regimen of 200+ Supplements (Updated Dec 30 2025)

Created for Me

Let me start by saying that this is MY personal health regimen. It was made for me, and only me. I created it by using SelfDecode to look at my genetic predispositions, experimenting with the recommendations, and doing my own research and tests to find what works best for my body.

I am clearly pushing the boundaries on what is normal, and perhaps even what is optimal. But I like to push the boundaries.

I always suggest that you follow a health regimen personalized for you. For that, I recommend SelfDecode, which tells you what the top recommended lifestyle and supplements are for your unique DNA.

For most people, I would recommend 5-10 supplements or a formula that contains the necessary ingredients. However, this is my profession and I’ve been taking and researching dietary supplements for the past 20 years, so I am quite more advanced in this area.

Admittedly, my regimen is pretty intense. I do take around 150 different supplemental ingredients a day, in the form of shakes and pills. Over the long term, I might cut back on the number of supplements. It will depend on what it takes to get all my labs and my personal goals in the optimal range – and if I get any negative side effects from taking so many supplements.

So far, my rate of aging is the slowest in the world (0.63) and almost all of my biomarkers are optimized. As long as my results are good, I will continue this approach.

This approach works better than Bryan Johnson’s Blueprint.

Criteria to Make It In My Regimen

To get in my regimen, it has to comply with at least 1/6 and usually all of the requirements here:

Placebo controlled trial showing effectiveness for one of my goals
Noticeable, positive effect in a mega-dosing experiment
Noticeable & positive change in a biomarker I want to improve
Benefit more than 1 goal of mine i.e. can’t just benefit one specific thing (Pleiotropic)
No significantly harmful side effects or long-term risks
Good personal fit – Improves biochemical or genetic pathway that is of particular interest to me

I want to be clear that I am not recommending megadosing experiments to the lay user, and that I am aware they do contain some risk. SelfDecode was created so that you don’t have to mega dose and you will have the knowledge about what to do to improve your health the most.

My Health Goals

In order for a supplement or lifestyle habit to be included in my regimen, it must go toward achieving some of my health goals:

Longevity – live to 120 without disease.
Health Span & Disease prevention (Cardiovascular disease, Cancer, Dementia, Kidney Disease, etc…) – prevent disease until 100.
Mood (high baseline happiness, no anxieties or fears, mentally & stress resilient, stable mood)
Energy, Wakefulness, Stamina, Motivation, Drive
Cognitive function (Focus/Attention, Working memory, Information processing, Verbal fluency, Long Term Memory, Creativity)
Immunity – to not get sick…(preventing infections, functioning well during infections, getting over them quickly)
Beauty: Hair, Skin, Nails, Teeth
Body composition (high muscle mass, low fat mass, 6 pack, etc..) & Strength
Great Sleep every night
Gut health
Quick recovery
No Pain (no aches or pains, rapid recovery from exercise, injuries, etc..)
Metabolic Health (never feeling hungry, while staying lean)
Empathy, Extraversion (when desired) & Social Intelligence

Tracking my Labs

It’s very important to track labs when taking supplements to make sure that you not only feel better but also things are working better “under the hood”.

A lot of supplements I take are there to enhance my lab values.

See this post: Measuring My Health: Lab Tests & Data Points I Track

The Supplements I Take

Fish oil (27 labs)
AcetylCarnitine – (27 labs) Testosterone, Acetylation, CPT2 variant
Vitamin C – (21 labs) Vitamin C, Copper, BUN, Albumin, Arginine, Ornithine, Ferritin, Homocysteine, ApoB, LDL, Hydroxyproline, Phosphorous, Lead, CH50, lowers Uric Acid
Vitamin D (20 labs)
Curcumin (18 labs)
Zinc (17 labs)
Black Seed (15 labs)
Flax oil – LP-PLA2 (13 labs)
NAC (12 labs) – homocysteine, LDH, Albumin
Chlorella – heavy metals (12 labs)
Spirulina – heavy metals (11 labs)
Taurine – longevity, mood (11 labs)
Magnesium (11 labs)
Garlic/Allicin – prostate cancer, CVD, infections (11 labs)
L Plantarum 299v (IgE – 11 labs)
Cinnamon (11 labs)
Sulforaphane – prostate cancer, GGT, Creatine Kinase (10 labs)
Whey protein (10 labs)
CoQ10/Ubiquinol (10 labs) – CAD, Parkinsons
Chromium – mood (10 labs) – causes foot pain?
Tocotrienols (10 labs) – CVD
AAKG (9 labs)
Shilajit – total and free T, SHBG (9 labs)
Citrulline serum)arginine, citrulline, creatinine, BUN (8 labs)
Boron (8 labs) – Free T, SHBG
Glutamine (8 labs)
Panax/American Labs) – cognition, mood, libido (8 labs)
Ginger (8 labs)
Ashwagandha – mood, libido (7 labs)
MSM (7 labs) – Sulfation, Immunity, recovery
Melatonin (7 labs) – 8 hallmarks
Astragalus (7 labs) – immunity
DHEA – DHEAS (7 labs)
Niacin (6 labs) – energy, food sensitivities
Calcium Carbonate (6 labs)
Inositol (6 labs)
TUDCA (6 labs) (GGT)
TMG – homocysteine (6 labs)
Green tea/EGCG – mood, longevity (6 labs)
Glycine – mood, longevity (5 labs), helped anxiety with 3600mg NAC
Histidine – longevity (5 labs)
Tryptophan – mood, food sensitivities, sleep – 1 hallmark
C15 – energy, (Protein, Albumin, RDW, ALT, AST, RBC+, Hemoglobin+, Hematocrit+)
B Longum BB536 (6 labs) – albumin
L Rhamnosus GG (TMAO, Albumin – 4 labs) – energy
B Lactis BB-12 (5 labs) – reduces gas
B lactis HN019 – Gut motility
L Reuteri DSM 17648 (4 labs) – reduces gas
L Acidophilus – 4 labs
S boulardii (CNCM I-745) – reduces gas
C Butyricum
B Breve M16V/BR03/Bbr8 (3 labs) – gas
B Bifidum
Pregnenolone – motivation
B6/P5P (4 labs)
Avena Sativa
Tongkat Ali – testosterone
Agmatine (3 labs)
Astragaloside IV/Cycloastragenol
Ecklonia Cava (4 labs)
Biotin – tinea, energy (4 labs)
Allithiamine
Methylcobalamin
L Norvaline (3 labs) – arginine, ornithine
Lysine (3 labs)
Serine (2 labs)
Leucine (2 labs) – serum protein
Borage oil (2 labs)
Potassium Chloride
Strontium
Molybdenum – Sulfation
Selenium – for NAC, T3/Free T3
Vitamin K2 – gums, nose bleeds
Kelp (for Iodine)
Ergothioneine (longevity, 1 lab)
Thiamine (1 lab)
Methylfolate
Anthocyanins (grapeseed ext)
Theobromine
Beta alanine (4 labs) – muscle
Creatine (4 labs)
Potassium Bicarbonate (CO2)
Glucosamine Sulfate (longevity)
Choline – Alpha GPC/Citicoline – HRV
Collagen (3 labs)
5HTP – mood
Lithium – mood, longevity
Rhodiola – mood
Bacognize – mood
Theanine – mood
Eleuthero – energy (1 lab)
PQQ (3 labs)
Kombucha – productivity
Carob – taste
Trehalose – taste
Cordyceps (IgE – 4 labs)
Reishi – immunity, mood – 8 hallmarks
Resistant Starch – fatigue, food sensitivities, mood, skin fungus (7 labs) – (moderate) unique -10g
Beta glucans – 250mg – unique
MOS – 500mg – unique
HMO (high tolerability) – unique – 500mg
Arabinogalactan (Acacia has this) (high tolerability) – unique – 1g
Inulin/FOS (low tolerability) – 500mg
GOS (moderate) – 500mg
PHGG (most tolerable) – 1g
Resistant Maltodextrin (high tolerability) – 1g
Psyllium Husk (Bile, high tolerability) – 1g
XOS (high tolerability) – 500mg
Vitamin A – hair, calazia, acne, immunity, thyroid (8 hallmarks)
Matcha or Tea – focus, mood, confidence
Arginine – (4 labs) energy, motivation, monogamy, anxiety – 8 hallmarks
Lycopene (CK – 5 labs) – prostate cancer
Lutein (AMD/Cataracts) – cataracts
Hydroxytyrosol
Astaxanthin (6 labs) – skin, parkinson’s, cataracts, cad – 8 Hallmarks
SAMe – (5 labs) Prolactin, Homocysteine, Methionine, Sulfation/PAPS,
Calcium D Glucarate – LDL? GGT?
Riboflavin
Manganese – Muscle pain, ALT, AST, ALP, Creatine Kinase, Glucose?, Free T3?, Bilirubin?
Vitamin E/Tocopherols
Citicoline/Alpha GPC
Carob
Urolithin A
Phosphatidylserine
Copper – bec of zinc and bile excretion, DHEA-S?
Threonine – serum protein
Valine – serum protein
Ebelin Lactones (0 labs)
Oroxylin A – Social, Focus, Motivation
Inosine – Motivation, Uric acid… insomnia/restlessness/pain?
Spermidine – longevity, CVD
Spleen (fresh)
Maitake
Shiitake
Chaga
Turkey tail
Colostrum
Silica
Epicatechin
Plasmalogens – longevity
Hydrogen
Nicotine
Uridine – dopamine receptor density, longevity
Royal Jelly (6 labs) – stem cells (powder)
Hyaluronic acid – skin
Bromelain – protein
Papain – protein, amylase
Ficin – protein, amylase
Pepsin – protein, amylase
Betaine HCL – protein, amylase
Digestive Enzymes
Carnosine
HMB (4 labs) – muscle
Butyrate – gut
Tributyrin – gut, DHEA-S?
Zinc carnosine – gut, DHEA-S?
DGL – gut
Alanyl-L-glutamine – gut
Trigonelline
Salidroside/Tyrosol
Nobiletin – circadian normalization, DHEA-S
Anserine
Paraxanthine
Pantethine
NMN – NAD
Nutritional Yeast – Immunity, Motivation
Finasteride + Minoxdil (topical)
MOTS-c – 1X/wk – DHEA-S? – 1X/wk
SS31 – 1X/wk – DHEA-S? – 1X/wk
Gaboxadol – 10mg – Sleep – 2X/wk
Esmirtazapine – Sleep – 2X/wk
Doxepin – Sleep – 2X/wk
Trazadone – 25mg (sleep) – 2X/wk
Activated Charcoal (9 labs) – wakefulness, motivation – 3X/wk
Ketamine mini dose – 15mg – 2X/wk
2-CB – creativity, emotionality, emotional intelligence, extroversion, stimulant – 1X/2 wk
LSD – creativity, emotionality, emotional intelligence, extroversion, stimulant – 1X/2 wk
Genistein
Quercetin (10 labs) – infection prevention
Ketones (Ketone Esters or Ketone salts)
Beet root or Potassium Nitrates (nitrates) – immunity
Artichoke extract
C8 oil – CPT2 variant
Chondrotin Sulfate
Forskolin (1 lab) – digestion, thyroid
Larazotide
KPV
BPC-157
Teacrine
CBD drops – 1mg THC (sleep) , fasting blood sugar, food sensitivities, gas
Low dose Rapamycin – 2mg/wk – Longevity, Food sensitivities
Emoxypine – 90mg – mood
Empagiflozin – HbA1c, Longevity, Uric acid decline,
Acarbose – HbA1c, Longevity
Tirzepatide – HbA1c, Longevity, LDL, DHEA-S, Amylase, Uric acid decline
Colesevelam – HbA1c, Apob
PCSK9i/Repatha – Lp(a), Apob
Ezetimibe (10mg) – Apob
Bempedoic acid (90mg) – Apob
Pitavastatin (1mg) – Apob
LDN – 2mg
Simethicone
17 alpha estradiol (longevity)

Foods:

Greens (smoothie/juice/vegetables)
Olive oil (EVOO)
Walnuts
Cayenne

Lifestyle/Devices:

40g Protein 3X a day, with carbs
Sauna
Weights
Bright light device
Whole Body Vibration
Red light mask
Red light cap
PEMF

Seldom:

Pregabalin 50mg – Sleep
Escitalopram microdose (2.5mg)
Tropisetron – cognition and focus
PT-141 (400mcg) – cognition/focus/sex drive
Mirtazapine – 3.75mg – Traveling
Lemborexant 5mg – Traveling

Taken out in 2025:

R Lipoic Acid – too many antioxidants, not enough benefits
Pterostilbene – too many antioxidants, not enough benefits
Alpha Carotene – too many antioxidants, not enough benefits
Geranylgeraniol – too many antioxidants, not enough benefits
Resveratrol – too many antioxidants, not enough benefits
Berberine – muscle pain
Saffron – heel pain
Fucoidan – bioavailability issues, no benefit noticed
Lactoferrin – lowered ferritin
Sceletium Tortuosum – muscle pain
St John’s Wort – issues with polypharmacy
Fucoxanthin & Punicic acid – not enough signal
Thymus glandular – not enough signal
Olive leaf extract – too many antioxidants
Poria – not enough signal
Cardamom – no signal
Vanadium – no signal
Bacopa (55% Baccosides) – unmotivated from it
Hypothalamus glandular – not enough benefit
Fo-Ti – not enough benefit
PABA – no noticeable benefit
Modified Citrus Pectin – not enough benefit
CLA – gas as a side effect, not enough benefit
Elderberry – no noticeable benefit
Tyrosine – didn’t like how I felt on it
Boswellia – muscle pain
Meclizine – immune suppression
Chamomile – not enough benefits
Thyroid hormones – not enough benefits

A/B testing:

Some substances, I A/B test over many years. For example, lion’s mane I’ve been taking on and off for many years. It had some benefits and some side effects, so it needs to be tested more carefully.

Imeglimin – HbA1c
Apple cider vinegar
Humanin
GHRP2
GHRP6
CJC1295
Tesmorelin
Ipamorelin
Binaural beats
Alpinia Galanga
Galantamine
Poria
Oleamide
PEA
Pinealon
Epitalon
Pyroglutamate
Cardamom
Bromantane
Celastrus
Lion’s Mane
Mitochonic Acid (synthetic derivatives of indole-3-propionic acid
Cyclo (his-pro)

Joe Cohen’s Regimen of 200+ Supplements (Updated Dec 30 2025)